The COMET tool rapidly classifies HIV-1 nucleotide sequences into subtypes. You can submit your sequences either by pasting them in the form (b) or uploading them (a).

2.4Additional support up to 118_BC, addition of subtypes not present before for HIV-12022-07-04
2.3Additional support for CRF 79_0107 - 96_cpx for HIV-12018-08-23
2.2Additional support for CRF 50_A1D - 78_cpx for HIV-12016-12-01
2.1Added bootstrap support levels (100 samples per sequence).2016-09-22
2.0Rewritten COMET in GO (Uses much less memory, faster; improved accuracy slightly).2016-09-18
1.0Smaller HIV-1 recombination detection window (should detect more URF), CRF additions to the training set2014-03-26
0.5new HIV-1 thresholds, should slightly improve the results2012-06-11
0.3Additional support for CRF 44_BF - 49_cpx for HIV-12011-12-20
0.1Initial version2010-03-27

Maximum size of each sequence (excluding fasta) 20000 characters

(a) upload the sequences in fasta format (you can compress the file with gzip, max. 8Mo (50MB)):

I confirm to use COMET only for non-commercial research purpose (*)

(b) paste the sequences in fasta format (try out example):

I confirm to use COMET only for non-commercial research purpose (*)

Privacy police:
The submitted sequences are deleted as soon the results have been generated.

If you use COMET, please cite:
Daniel Struck; Glenn Lawyer; Anne-Marie Ternes; Jean-Claude Schmit; Danielle Perez Bercoff. COMET: adaptive context-based modeling for ultrafast HIV-1 subtype identification. Nucleic Acids Research 2014; doi: 10.1093/nar/gku739 (full text)

Supplementary information:
HIV-1 training set

(*) The COMET-HIV and COMET-HCV services provided herein are "For non-commercial research use only". For all commercial uses, please contact our Exclusive Licensee, ABL SA ( at